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Expression of CXCR4 on T-cell subsets and Plasma IL-17 Concentrations in Patients with Aplastic Anaemia.

Expression of CXCR4 on T-cell subsets and Plasma IL-17 Concentrations in Patients with Aplastic Anaemia.
Author Information (click to view)

Niu Q, Zhou Q, Liu Y, Jiang H,


Niu Q, Zhou Q, Liu Y, Jiang H, (click to view)

Niu Q, Zhou Q, Liu Y, Jiang H,

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Scientific reports 2017 08 227(1) 9075 doi 10.1038/s41598-017-08699-z

Abstract

Acquired aplastic anaemia (AA) is caused by T-cells migrating to and attacking bone marrow (BM) in response to chemokines (e.g., CXCR4). We investigated CXCR4 expressions on circulating T-cell subsets, plasma IL-17A concentrations, and their correlations with AA manifestations. We enrolled 71 patients with acquired AA (36 severe AA cases [SAA] and 35 non-severe AA cases [NSAA]) and 42 healthy volunteers. We used flow cytometry and ELISA to measure circulating CD4(+) and CD8(+) T-cells, their CXCR4 expressions, and plasma IL-17A concentrations. Compared to the healthy controls, SAA patients had fewer peripheral CD4(+) T-cells, more CD8(+) T-cells, and a significantly decreased CD4(+)/CD8(+) ratio which was positively correlated with AA manifestations. Patients with SAA or NSAA had higher proportions of CD4(+)CXCR4(+) and CD8(+)CXCR4(+) T-cells, which were negatively correlated with haemoglobin concentrations and absolute neutrophil counts. Patients with SAA or NSAA had higher plasma IL-17A concentrations, which were negatively correlated with AA manifestations and the CD4(+)/CD8(+) ratio. IL-17A concentrations showed a very week correlation with CD4(+)CXCR4(+) T-cells frequencies, and no correlation with CD8(+)CXCR4(+) T-cells frequencies. Aberrant CXCR4 expression may allow circulating T-cells, especially CD8(+) T-cells, to infiltrate BM during AA progression. Elevated IL-17A concentrations may contribute to AA progression outside of the CXCR4-SDF-1α axis.

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