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Expressions of insulin-like growth factor receptor-1 and cezanne-1 in lung adenocarcinoma.

Expressions of insulin-like growth factor receptor-1 and cezanne-1 in lung adenocarcinoma.
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Pang Z, Cui L, Ding N, Zhu L, Qu X, Dong W, Du J, Liu Q,


Pang Z, Cui L, Ding N, Zhu L, Qu X, Dong W, Du J, Liu Q, (click to view)

Pang Z, Cui L, Ding N, Zhu L, Qu X, Dong W, Du J, Liu Q,

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Medical oncology (Northwood, London, England) 2017 04 0134(5) 78 doi 10.1007/s12032-017-0934-1
Abstract

IGF1R (insulin-like growth factor receptor-1) was confirmed to play a significant role in the development of cancer. Cezanne-1 overexpression was considered to be associated with enhancement of EGFR signaling pathway and reduced degeneration of EGFR. There was a close relationship between EGFR and IGFR as previous study showed. Dynamic balance between receptor ubiquitination and deubiquitination was critical in the process of termination of IGF signaling pathway. So we conducted an IHC staining to initially prove the correlation. Cezanne-1 and IGF1R expressions were evaluated in 103 patients with lung adenocarcinoma using immunohistochemical (IHC) analysis. The relationship between expressions of cezanne-1 and IGF1R were analyzed by χ2 test. Kaplan-Meier method was used to generate the survival curve, and the statistical difference was calculated by log-rank test. We also used data in R2 system to verify the relationship between IGF1R and cezanne-1. R2 system showed there was a close correlation between IGF1R and cezanne-1. Positive expression of cezanne-1 was detected in 64.1% patients. A significant association was shown between cezanne-1 and IGF1R expression (p < 0.001). Multivariate analysis confirmed that both cezanne-1 and IGF1R expressions were independent prognostic factors for OS. (HR 2.96, 95% CI 1.090-8.060, p = 0.033; HR 2.273, 95% CI 1.016-5.085, p = 0.046, respectively). Our findings indicated both cezanne-1 and IGF1R expressions were negative independent predictive factors for the prognosis of lung adenocarcinoma, respectively. There was a close positive interrelationship between cezanne-1 and IGF1R expression.

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