There is hardly any country that has not been affected by the COVID-19. But yet, the actual cause of mortality is unclear. This study aims to describe the outcomes of people admitted to hospitals with COVID-19, and the clinical and laboratory characteristics associated with the illness.

This is a prospective cohort study conducted in a single academic medical center in New York and Long Island. It included 5,279 patients with laboratory-confirmed SAES-CoV-2 infection. The patients were evaluated on characteristics, medical history, vital signs, and laboratory results.

Out of 5,270 COVID-19-positive patients, 2,741 were admitted to the hospital, 1904 of whom were discharged alive without hospice care. Out of the remaining 665 patients, 647 required mechanical ventilation, 391 died, and 170 were released or extubated. The most influential factor associated with hospital admission was age, with an odds ratio of (>2) for adults older than 44 years and (37.9) for adults aged 75 and older. Other risks included heart failure, chronic kidney disease, and heart failure. Admission oxygen saturation was primarily associated with a critical illness.

The research concluded that age and comorbidities were the strongest predictors of hospital admission. Impairment of oxygen on admission, along with the signs of inflammation, was most strongly associated with critical illness and mortality.