It is necessary and urgent to vaccinate 245 million Chinese children against influenza pandemics. The main purpose of this study was to evaluate different psychological and demographic factors that influence parental willingness to vaccinate their children against influenza.

A hybrid theoretical framework was expanded and verified with 462 sample data collected from four cities in China. Structural equation models were used to test nine theoretical hypotheses, and Researchers used the non-standardized coefficient method to discuss the moderating effects among demographic variables.

Knowledge is considered the significant factor of performance expectancy, effort expectancy, and perceived risk, and social influence also has significant impacts on the above three variables, with β values of 0.437, 0.386, and −0.172. Performance expectancy, effort expectancy, and perceived risk significantly affect parental behavioral intention regarding children’s influenza vaccination. Gender, education, and kids’ gender are demographic variables with significant moderating effects, while age, income, number of kids are not substantial.

The study concluded that the promoting policies should emphasize public knowledge and social influence, as well as effectiveness, affordability, and safety of vaccination to improve the acceptability of influenza vaccination among Chinese children.