A rising body of data implied that intrapancreatic fat is connected with diabetes, however, it is uncertain whether intrapancreatic fat distribution throughout pancreatic areas has a pathophysiologic function. For a study, researchers sought to determine the differences in intrapancreatic fat deposition between the pancreas’ head, body, and tail, as well as the link between regional intrapancreatic fat deposition and diabetes status and insulin characteristics. A total of 368 persons from the general community were scanned with a 3 Tesla scanner, and intrapancreatic fatwas manually measured in triplicate. Age, gender, ethnicity, BMI, and liver fat were all taken into account in the statistical models. 

In adjusted models, intrapancreatic fat deposition in the head, body, and tail of the pancreas did not vary substantially in the total cohort or the three subgroups depending on diabetes status. Insulin resistance and fasting insulin were substantially related to fat in the pancreas’ tail and body. There was no statistically significant relationship between regional intrapancreatic fat and HOMA of -cell function. The link between increased intrapancreatic fat deposition in the tail and body regions and greater insulin resistance may play a significant role in identifying people at risk of developing insulin resistance and the illnesses that result from it.

Reference:diabetesjournals.org/diabetes/article-abstract/71/6/1182/144633/Fat-Distribution-Within-the-Pancreas-According-to?redirectedFrom=fulltext