Multiple organizations, including the American Society for Reproductive Medicine, the World Professional Association for Transgender Health, and the Endocrine Society, supported fertility preservation counseling in the transgender patient group. The best time to attempt fertility preservation has yet to be determined, and research on the possible consequences of testosterone treatment on future reproductive potential was few. The Current Commentary aimed to determine the best timing to execute oocyte cryopreservation in relation to time on and off testosterone medication, individual age, and emotional impact of treatment. Despite several research demonstrating effective oocyte cryopreservation independent of testosterone exposure, data on live-birth rates following oocyte cryopreservation are scarce.

Furthermore, given the feminizing effects of gonadotropin stimulation, the invasiveness of pelvic ultrasonograms, and the oocyte-retrieval method, the process of oocyte cryopreservation may have a major negative emotional impact on the transgender guy. The research demonstrated the need for a comprehensive, tailored approach to fertility-preservation counseling and the timing of therapy. Postponing fertility-preservation operations till patients reach early adulthood may be considered to prevent the negative impact on mental health while maintaining results.