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Food intake and darunavir plasma concentrations in people living with HIV in an outpatient setting.

Food intake and darunavir plasma concentrations in people living with HIV in an outpatient setting.
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Daskapan A, Dijkema D, de Weerd DA, Bierman WFW, Kosterink JGW, van der Werf TS, Alffenaar JWC, Stienstra Y,


Daskapan A, Dijkema D, de Weerd DA, Bierman WFW, Kosterink JGW, van der Werf TS, Alffenaar JWC, Stienstra Y, (click to view)

Daskapan A, Dijkema D, de Weerd DA, Bierman WFW, Kosterink JGW, van der Werf TS, Alffenaar JWC, Stienstra Y,

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British journal of clinical pharmacology 2017 07 07() doi 10.1111/bcp.13366

Abstract

Patients receiving darunavir are advised to take it concomitantly with food. The objectives of this study were to evaluate the actual concomitant food intake of patients visiting an HIV outpatient clinic. In this cross-sectional study participants treated with darunavir/ritonavir once daily were subjected to a food recall-questionnaire concerning their last concomitant food intake with darunavir. Darunavir trough concentrations were calculated. For the 60 participants the median food intake was 507 (0 – 2707) kcal; protein intake, 20 (0 – 221)g; carbohydrates, 62 (0 – 267)g; fat intake: 14 (0 – 143)g; and dietary fiber: 4 (0 – 30)g. Twenty-five patients (42%) ingested their drug with in-between meals. No relation was found between food intake and trough concentrations. Clear advice on the optimal caloric intake is needed to avoid high caloric intake in patients who already have an increased risk of cardiovascular disease due to their HIV infection.

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