The study was done to report the foveal cone count in eyes with resolved endophthalmitis vis-à-vis normal fellow eyes using an indigenous AO-SLO.

In a prospective cross-sectional comparative pilot study, we recruited patients with resolved endophthalmitis in one eye and a normal fellow eye (control eye). Collected data included measurement of the best-corrected visual acuity (BCVA), spectral-domain OCT imaging and AO-SLO imaging and cone counting at the fovea in both eyes.

The study included 12 eyes of 6 patients. The mean age was 51.66±11.97 years (median 56 years). BCVA in all control eyes was 20/20 (logarithm of the minimum angle of resolution (LogMAR) 0), and in the study, eyes was 0.21±0.13 (median 0.19, Snellen 20/30; p=0.001; 95% CI −0.39 to −0.09). The follow-up was 18.66±12.32 (median 20 months). The cone count at the fovea in the control eye was 4356.33±1993.93 (median 4498), and in the study eye, it was 2357.16±1541.17 (median 2187.5; p=0.03; 95% CI −3556 to −1082).

The study concluded that eyes with resolved endophthalmitis with near-normal vision have reduced number of foveal cones even in absence of OCT-detected gross structural changes.