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Fragile sites in cancer: more than meets the eye.

Fragile sites in cancer: more than meets the eye.
Author Information (click to view)

Glover TW, Wilson TE, Arlt MF,


Glover TW, Wilson TE, Arlt MF, (click to view)

Glover TW, Wilson TE, Arlt MF,

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Nature reviews. Cancer 17(8) 489-501 doi 10.1038/nrc.2017.52

Abstract

Ever since initial suggestions that instability at common fragile sites (CFSs) could be responsible for chromosome rearrangements in cancers, CFSs and associated genes have been the subject of numerous studies, leading to questions and controversies about their role and importance in cancer. It is now clear that CFSs are not frequently involved in translocations or other cancer-associated recurrent gross chromosome rearrangements. However, recent studies have provided new insights into the mechanisms of CFS instability, their effect on genome instability, and their role in generating focal copy number alterations that affect the genomic landscape of many cancers.

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