Advertisement

 

 

Frailty is an independent prognostic marker in elderly patients with myocardial infarction.

Frailty is an independent prognostic marker in elderly patients with myocardial infarction.
Author Information (click to view)

Alonso Salinas GL, Sanmartin M, Pascual Izco M, Rincon LM, Pastor Pueyo P, Marco Del Castillo A, Garcia Guerrero A, Caravaca Perez P, Recio-Mayoral A, Camino A, Jimenez-Mena M, Zamorano JL,


Alonso Salinas GL, Sanmartin M, Pascual Izco M, Rincon LM, Pastor Pueyo P, Marco Del Castillo A, Garcia Guerrero A, Caravaca Perez P, Recio-Mayoral A, Camino A, Jimenez-Mena M, Zamorano JL, (click to view)

Alonso Salinas GL, Sanmartin M, Pascual Izco M, Rincon LM, Pastor Pueyo P, Marco Del Castillo A, Garcia Guerrero A, Caravaca Perez P, Recio-Mayoral A, Camino A, Jimenez-Mena M, Zamorano JL,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Clinical cardiology 2017 07 16() doi 10.1002/clc.22749
Abstract
BACKGROUND
Acute coronary syndrome (ACS) patients are increasingly older. Conventional prognostic scales include chronological age but do not consider vulnerability. In elderly patients, a frail phenotype represents a better reflection of biological age.

HYPOTHESIS
This study aims to determine the prevalence of frailty and its influence on patients age ≥75 years with ACS.

METHODS
Patients age ≥75 years admitted due to type 1 myocardial infarction were included in 2 tertiary hospitals, and clinical data were collected prospectively. Frailty was defined at admission using the previously validated Survey of Health Ageing and Retirement in Europe Frailty Index (SHARE-FI) tool. The primary endpoint was the combination of death or nonfatal myocardial reinfarction during a follow-up of 6 months. Major bleeding (hemoglobin decrease ≥3 g/dL or transfusion needed) and readmission rates were also explored.

RESULTS
A total of 234 consecutive patients were included. Frail patients (40.2%) had a higher-risk profile, based on higher age and comorbidities. On multivariate analysis, frailty was an independent predictor of the combination of death or nonfatal myocardial reinfarction (adjusted hazard ratio [aHR]: 2.54, 95% confidence interval [CI]: 1.12-5.79), an independent predictor of the combination of death, nonfatal myocardial reinfarction, or major bleeding (aHR: 2.14, 95% CI: 1.13-4.04), and an independent predictor of readmission (aHR: 1.80, 95% CI: 1.00-3.22).

CONCLUSIONS
Frailty phenotype at admission is common among elderly patients with ACS and is an independent predictor for severe adverse events. It should be considered in future risk-stratification models.

Submit a Comment

Your email address will not be published. Required fields are marked *

twenty + twelve =

[ HIDE/SHOW ]