Patients with HFrEF and greater frailty experienced poorer clinical and therapeutic outcomes, according to findings published in JACC: Heart Failure. In an analysis of 879 patients, Shahzeb Khan, MD, and colleagues found that 56.3% had a high frailty burden; when compared with no frailty, such a burden was associated with a greater risk for HF hospitalization or death (HR, 1.76), as well as a decreased likelihood of receiving guideline-directed medical therapy at study end (17.7% vs 28.4%).