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Fructose metabolism and metabolic disease.

Fructose metabolism and metabolic disease.
Author Information (click to view)

Hannou SA, Haslam DE, McKeown NM, Herman MA,


Hannou SA, Haslam DE, McKeown NM, Herman MA, (click to view)

Hannou SA, Haslam DE, McKeown NM, Herman MA,

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The Journal of clinical investigation 2018 02 01128(2) 545-555 doi 10.1172/JCI96702
Abstract

Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of sugar may be particularly harmful. Diets high in fructose can rapidly produce all of the key features of the metabolic syndrome. Here we review the biology of fructose metabolism as well as potential mechanisms by which excessive fructose consumption may contribute to cardiometabolic disease.

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