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Gastric Acid Suppression Medications Increase Risk for Recurrence of Clostridium Difficile Infection

Gastric Acid Suppression Medications Increase Risk for Recurrence of Clostridium Difficile Infection
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Mayo Clinic


Mayo Clinic (click to view)

Mayo Clinic

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Researchers at Mayo Clinic have found patients who use gastric suppression medications are at a higher risk for recurrent Clostridium difficile (C-diff) infection. C-diff is a bacterium that can cause symptoms ranging from diarrhea to life-threatening inflammation of the colon. The study is published in JAMA Internal Medicine.

“In our study, we found that use of gastric acid suppression medications are associated with a statistically significant increased risk of development of recurrent C-diff in patients with a prior episode of C-diff,” says Sahil Khanna, M.B.B.S., a gastroenterologist at Mayo Clinic and senior author of the study.

Dr. Khanna says gastric suppression medications studied include proton pump inhibitors, such as omeprazole, and histamine 2 blockers, such as ranitidine, which are commonly prescribed and consumed over-the-counter medications for gastroesophageal reflux disease, peptic ulcer disease or dyspepsia.


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In a systematic review and meta-analysis of 16 studies with 7,703 patients with C-diff, 1,525 developed recurrent C-diff. The rate of recurrent C-diff in patients with gastric suppression was 22.1%, compared to 17.3% in patients without gastric acid suppression.

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