Journal of cardiac failure 2017 01 10() pii S1071-9164(17)30003-9
This study was conducted to determine the association between aortic pulse pressure (APP) and left ventricular (LV) filling pressure in the elderly of both genders.
A total of 211 stable elderly subjects (age ≥ 65 years, mean age 72.1 ± 5.2 years, 53.6% women) who underwent invasive coronary angiography (ICA) for the evaluation of coronary artery disease (CAD) were prospectively investigated. APP was measured in the ascending aorta using a pigtail catheter immediately before ICA. E/e’, reflecting LV filling pressure, was assessed by transthoracic echocardiography.
There were positive linear correlations between APP and E/e’ in both genders, but the correlation power was stronger in women than in men (r = 0.482, P < 0.001 versus r = 0.208, P = 0.040). The significance of this association between APP and E/e' remained after controlling for potential confounders in multiple linear regression analysis only in women (β = 0.359, P < 0.001), but not in men (r = 0.139, P = 0.108). CONCLUSIONS
Invasively measured APP is independently associated with E/e’ in elderly women, but not in elderly men undergoing ICA. Aortic stiffness may be a potential mechanism for more prevalent LV diastolic dysfunction and heart failure with preserved ejection fraction in elderly women.