Advertisement

 

 

Gene Fusion in Malignant Glioma: An Emerging Target for Next-Generation Personalized Treatment.

Gene Fusion in Malignant Glioma: An Emerging Target for Next-Generation Personalized Treatment.
Author Information (click to view)

Xu T, Wang H, Huang X, Li W, Huang Q, Yan Y, Chen J,


Xu T, Wang H, Huang X, Li W, Huang Q, Yan Y, Chen J, (click to view)

Xu T, Wang H, Huang X, Li W, Huang Q, Yan Y, Chen J,

Advertisement

Translational oncology 2018 03 2011(3) 609-618 pii S1936-5233(18)30044-5
Abstract

Malignant gliomas are heterogeneous diseases in genetic basis. The development of sequencing techniques has identified many gene rearrangements encoding novel oncogenic fusions in malignant glioma to date. Understanding the gene fusions and how they regulate cellular processes in different subtypes of glioma will shed light on genomic diagnostic approaches for personalized treatment. By now, studies of gene fusions in glioma remain limited, and no medication has been approved for treating the malignancy harboring gene fusions. This review will discuss the current characterization of gene fusions occurring in both adult and pediatric malignant gliomas, their roles in oncogenesis, and the potential clinical implication as therapeutic targets.

Submit a Comment

Your email address will not be published. Required fields are marked *

eight + two =

[ HIDE/SHOW ]