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Genetic Analysis of HIV-1 in Japan: a Comprehensive Analysis of Donated Blood.

Genetic Analysis of HIV-1 in Japan: a Comprehensive Analysis of Donated Blood.
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Matsumoto C, Shinohara N, Sobata R, Uchida S, Satake M, Tadokoro K,


Matsumoto C, Shinohara N, Sobata R, Uchida S, Satake M, Tadokoro K, (click to view)

Matsumoto C, Shinohara N, Sobata R, Uchida S, Satake M, Tadokoro K,

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Japanese journal of infectious diseases 2016 06 3070(2) 136-142 doi 10.7883/yoken.JJID.2015.504

Abstract

In Japan, the number of human immunodeficiency virus (HIV)-1 infections remains relatively low; nevertheless, the annual incidence of HIV-1 infection has not decreased. New infections remain a great concern, and an improved understanding of epidemiological trends is critical for public health. The env C2V3 and pol sequences of HIV-1 RNA from 240 early (1996-2001) and 223 more recent (2010-2012) blood donations were used to compare the distribution of virus subtypes and to generate phylogenetic trees. Subtype B was clearly predominant in both early and more recent donations (both were 88.3%), and CRF01_AE was the second most common subtype. Phylogenetic analysis revealed a peculiar epidemiological transition. Compared to early subtype B isolates from 2 major endemic areas (Tokyo and Osaka), the more recent subtype B isolates formed fewer tight clusters in phylogenetic trees (from 8 to 2 clusters in Tokyo and 5 to zero clusters in Osaka). Furthermore, mixing of HIV-1 infections between these 2 endemic areas appear to increase. Analysis of phylogenetic trees suggested that local outbreaks have become smaller in Japan; however, intermixing of viral types between these 2 areas was more evident in the more recent samples.

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