The atomic elements like fibroid (Nrf2) are the enzymes that play a pivotal role in upregulating the key cell protections. There have been various kinds of studies and research to prove that the clinical preliminaries are using pharmacologic Nrf2 inducers, for example, bardoxolone methyl to treat ongoing kidney malady, however Nrf2 enactment has been connected to an incomprehensible increment in; proteinuria. To comprehend this impact, we inspected hereditarily designed mice with raised. Contrasted with angiotensin II alone, the mix of angiotensin II and CDDO-Im essentially expanded proteinuria, a marvel does not see in Nrf2 knockout mice. This impact was not joined by extra increments in circulatory strain. At long last, Nrf2 was discovered to be upregulated in the glomeruli of patients with central segmental glomerulosclerosis, diabetic nephropathy, fibrillary glomerulonephritis, and membranous nephropathy. Hence, an attempt must be made to cure the people in the best possible manner.

Ref art: https://www.kidney-international.org/article/S0085-2538(20)30952-2/fulltext