Human papillomavirus (HPV) genotype distribution and prevalence among women fluctuate among areas and populations; nevertheless, preventive HPV vaccination might prevent various HPV-related illnesses such as cervical precancerous lesions and cancer. Prior to widespread HPV vaccination, baseline surveys are essential for determining vaccine effectiveness and detecting changes in HPV type following vaccination. The purpose of this study is to look at the HPV type-specific prevalence in 698 women with cytological abnormalities ranging in age from 18 to 77. The Thinprep liquid-based cytologic test (TCT) was done, and the cytological status was categorised using Bethesda 2001 criteria. The HPV genotype was determined using a PCR-based hybridization gene chip assay on the samples. Overall, the HPV prevalence was 54.87 per cent, with a declining and zigzag prevalence until the age of 55. 204 individuals had pure high-risk HPV, 139 had pure low-risk HPV, and 40 had mixed HPV strains. The most prevalent kind was HPV16, followed by HPV58 and HPV52. 386 people were afflicted by ASCUS, 11 by ASC-H, 137 by L-SIL, and 151 by H-SIL in this research. Women having cytology results of ASCUS, ASC-H, L-SIL, and H-SIL were infected with HPV in 39.12 per cent, 54.17 per cent, 70.80 per cent, and 80.79 per cent of the cases, respectively.

Finally, this study is the first to look at the incidence of HPV infection and HPV genotype distribution in Xinjiang women with abnormal cytological testing. The findings might serve as baseline data and a validation set prior to HPV immunisation in the Xinjiang population, providing strong accessible estimates of the prevalence of type-specific HPV.

Reference: https://www.tandfonline.com/doi/full/10.1080/21645515.2019.1578598