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Genotype distribution and treatment response among incarcerated drug-dependent patients with chronic hepatitis C infection.

Genotype distribution and treatment response among incarcerated drug-dependent patients with chronic hepatitis C infection.
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Cheng CH, Lin CC, Chen HL, Lin IT, Wu CH, Lee YK, Bair MJ,


Cheng CH, Lin CC, Chen HL, Lin IT, Wu CH, Lee YK, Bair MJ, (click to view)

Cheng CH, Lin CC, Chen HL, Lin IT, Wu CH, Lee YK, Bair MJ,

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PloS one 2018 02 0113(2) e0191799 doi 10.1371/journal.pone.0191799
Abstract

The prevalence of hepatitis C virus (HCV) infection is disproportionately high among prisoners, especially among those who are drug-dependent. However, current screening and treatment recommendations are inconsistent for this population, and appropriate care is not reliably provided. To address these problems, the present study aimed to identify unique characteristics and clinical manifestations of incarcerated patients with HCV infection. We included incarcerated patients who received treatment with pegylated-interferon combined with ribavirin at Mackay Memorial Hospital in Taitung and were serving sentences at either the Taiyuan Skill Training Institute or the Yanwan Training Institute. HCV genotypes 1 (41.4%), 3 (25.9%), and 6 (24.1%) were the most prevalent in the incarcerated patients. During the study period, we analyzed treatment response among 58 incarcerated patients and compared obtained results with treatment response among 52 patients who were living in the community. Higher sustained virological response rate was observed among patients with incarceration and HCV genotype other than 1. The odds ratios (corresponding 95% confidence intervals) for incarceration and genotype 1 were 2.75 (1.06-7.11) and 0.37 (0.14-0.99), respectively. Better treatment compliance among incarcerated patients might partially explain these results. The results of this study suggest that treatment of prisoners with HCV infection is feasible and effective. More appropriate and timely methods are needed to prevent HCV transmission among injection drug users inside prisons.

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