Scleroderma (SSc)‐associated gastrointestinal (GI) complications are attributed to various factors, including diet, microbiota dysbiosis, or GI transit abnormalities. This study examined the contribution of abnormal GI transit to SSc Medsger GI severity scores and UCLA GIT 2.0 symptoms. Patients with SSc and GI symptoms (n=71) and healthy controls (n=18) underwent whole gut transit (WGT) scintigraphy to assess transit from the esophagus to the colon. The presence of delayed transit and percent emptying in each GI region were measured.
Eighty percent of patients had >1 abnormal region of the gut on WGT scintigraphy. All patients requiring total parenteral nutrition had delayed small bowel transit, compared to only ~11% of patients in other Medsger GI severity groups (p=<0.01). Severe colonic transit delays were more likely in patients with Medsger GI scores of 3 (pseudo‐obstruction and malabsorption) than other Medsger GI groups (p=0.02). Seventy percent of these patients had ≤30% colonic emptying at 72 hours. Modest associations were noted between GERD symptoms and delayed esophageal (r=‐0.31,p=0.05) and gastric emptying (r=‐0.32,p=0.05).
These data are essential in providing evidence that SSc bowel disease affects transit of GI content and that delay in transit accounts in part for both bowel symptoms and Medsger GI severity.
Ref: https://onlinelibrary.wiley.com/doi/10.1002/acr.24488
