The global burden of diabetic nephropathy increased from 1990 to 2021 and is projected to continue increasing until 2050, according to a study published in Frontiers in Endocrinology. Researchers used data from 1990 to 2021 to analyze trends and future projections of the worldwide burden of chronic kidney disease (CKD) caused by type 1 and type 2 diabetes mellitus. Trends in the burden of each disease subtype and different regions were calculated using Estimated Annual Percentage Changes (EAPCs). Th e burden of diabetic nephropathy and its EAPCs varied significantly across different sociodemographic index subgroups of countries and regions worldwide. Th ere was also signifi cant variability in the influence of age and metabolic factors on the burden of diabetic nephropathy. Th ere was a positive correlation between the effects of metabolic factors on the number of deaths and mortality with age. Modeling showed the global burden of diabetic nephropathy is predicted to continue increasing in the absence of interventions from 2022 to 2050.
