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GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor.

GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor.
Author Information (click to view)

Fusco J, Xiao X, Prasadan K, Sheng Q, Chen C, Ming YC, Gittes G,


Fusco J, Xiao X, Prasadan K, Sheng Q, Chen C, Ming YC, Gittes G, (click to view)

Fusco J, Xiao X, Prasadan K, Sheng Q, Chen C, Ming YC, Gittes G,

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Scientific reports 2017 08 227(1) 9100 doi 10.1038/s41598-017-09898-4
Abstract

Exendin-4 is a long acting glucagon-like peptide 1 (GLP-1) analogue that is an agonist for the GLP-1 receptor, a G-protein coupled receptor (GPCR). Exendin-4 is used to clinically improve glucose tolerance in diabetic patients due to its ability to enhance insulin secretion. In rodents, and possibly in humans, exendin-4 can stimulate β-cell proliferation. The exact mechanism of action to induce β-cell proliferation is not well understood. Here, using a β-cell specific epidermal growth factor receptor (EGFR) null mouse, we show that exendin-4 induced an increase in proliferation and β-cell mass through EGFR. Thus, our study sheds light on the role of EGFR signaling in the effects of exendin-4 on the control of blood glucose metabolism and β-cell mass.

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