After eating, enteroendocrine L-cells produce glucagon-like peptide 2 (GLP-2). In the stomach, it appears to have trophic effects. Children with diarrhea and malnutrition were tested for GLP-2 levels in the blood. Children with acute diarrhea, throughout sickness and 3 weeks after recovery; persistent diarrhea and severe acute malnutrition; controls contemporaneous for diarrhea; community stunted children; and community stunt children’s controls contemporaneous with the community stunts. Stool biomarkers and pathogen analyses were performed on stunted children. GLP-2 levels were greater during acute diarrhea than after recovery, but not in children with chronic diarrhea and severe acute malnutrition. GLP-2 levels in stunted children decreased gradually from 3.2 ng/mL to 1.0 as the children got more stunted. In multivariable analysis, seasonality was found to be substantially related to GLP-2 concentrations. The study also discovered a link between inflammatory indicators in the feces and GLP-2.
GLP-2 levels rose in acute diarrhea but not in chronic diarrhea. Malnutrition was linked to lower concentrations. GLP-2 showed seasonal fluctuation, which corresponded to changes in nutrient availability.