Pediatric clinical practice guidelines (CPGs) have lacked a full review in recent years. Researchers evaluated the quality of pediatric CPGs in a study, taking into account aspects that could affect their quality. The aim of the study was to encourage a better-coordinated development and deployment of CPGs. Between 2017 and 2019, pediatric CPGs were searched and collected in Organizations. Using the Appraisal of Guidelines for Research and Evaluation II, paired researchers conducted screening, data extraction, and quality assessment (AGREE II). The parameters affecting the quality of CPGs were determined using linear regression analysis.

The AGREE II assessment yielded a mean score of 4.26 out of 7 points (60.86%) for the 216 CPGs in the study. Only 6.48% of CPGs were deemed “recommendable.” The remaining 69.91% should have been altered before recommendation, and the remaining 23.61% did not meet the suggested standard at all. The general quality of contemporary pediatric CPGs has improved, and the fraction of low-quality CPGs has reduced over time. However, there were still far too few CPGs that met the criteria for excellent quality. The domains of “applicability” and “rigor of development” received low marks. As independent or combinatorial factors, CPGs formed by developing countries or regions, those not under the control of an organization or group, and those using non-evidence-based approaches were associated with inferior quality in several sectors. Pediatric CPGs still need to be improved in terms of quality. They performed Quality control to assure the quality and applicability of new CPGs.