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Health-Related Quality of Life in Adolescent Patients with Hepatitis C Genotype 1 Treated with Sofosbuvir and Ledipasvir.

Health-Related Quality of Life in Adolescent Patients with Hepatitis C Genotype 1 Treated with Sofosbuvir and Ledipasvir.
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Younossi ZM, Stepanova M, Balistreri W, Schwarz K, Murray KF, Rosenthal P, Bansal S, Hunt S,


Younossi ZM, Stepanova M, Balistreri W, Schwarz K, Murray KF, Rosenthal P, Bansal S, Hunt S, (click to view)

Younossi ZM, Stepanova M, Balistreri W, Schwarz K, Murray KF, Rosenthal P, Bansal S, Hunt S,

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Journal of pediatric gastroenterology and nutrition 2017 09 27() doi 10.1097/MPG.0000000000001754
Abstract
OBJECTIVE
To assess the impact of treatment with ledipasvir/sofosbuvir (LDV/SOF) on the health-related quality of life (HRQL) of pediatric patients with chronic hepatitis C virus (HCV) infection.

METHODS
Adolescents (12-17 years) with HCV were treated with LDV/SOF (90 mg/400 mg daily) for 12 weeks. HRQL was assessed using the PedsQLv4.0-SF15 completed by the children and caregivers before, during, and after treatment.

RESULTS
We included 100 adolescents with HCV genotype 1 infection [14.7 ± 2.0 years, 1% known cirrhosis, 80% treatment-naïve, 97% sustained virologic response (SVR-12)]. At baseline, HRQL the caregiver- perceived HRQL scores were lower than adolescents’ self-reported scores (by 6.7-7.9 points, all p < 0.01). At the end of 12 weeks of treatment, however, the caregiver-reported HRQL scores showed a significant improvement (+all p < 0.04) whereas the adolescents' self-reported scores did not change from the baseline. HRQL scores reported by caregivers remained higher than baseline (by +4.7 to +7.5, p < 0.01) through 12 weeks post-treatment, as did the adolescents' self-reported Emotional Functioning scores (+4.3 from baseline, p = 0.0009); observed improvements were sustained after 24 weeks of follow-up (all p < 0.04). Multivariate analysis showed that, after adjustment for location, age, and gender, having a history of anxiety and panic disorders were consistent predictors of impaired HRQL in adolescents with HCV infection (p < 0.05). CONCLUSIONS
Treatment of HCV in adolescents with LDV/SOF is associated with some improvement in HRQL. Caregivers’ reports of HRQL in adolescents with HCV significantly increased with treatment and were similar to the adolescent self-reported HRQL after SVR-12.

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