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The QoL ratings were similar across ages in individuals on non-invasive support for chronic respiratory failure, though flare-ups, dependence, and low blood levels affected age groups differently.

According to a study published in the June 2025 issue of BMC Pulmonary Medicine, researchers evaluated the factors influencing QoL among older adults (OAs) receiving non-invasive ventilation (NIV) for chronic hypercapnic respiratory failure (CHRF).   

They assessed health-related quality of life (HRQL) using the Severe Respiratory Insufficiency Questionnaire (SRI) in a single-center study registered on 17 June 2015 (DRKS00008759). Participants were divided into 2 age groups: ≥ 65 years and < 65 years. A total of 237 individuals with CHRF receiving NIV were included, and multiple linear regression was also applied to assess associations between QoL and variables, including SRI scores, anemia, exacerbation history, and levels of autonomy impairment.   

The results showed that 237 individuals with Chronic Obstructive Pulmonary Disease (COPD) and CHRF undergoing NIV had a mean SRI summary score of 49.9 ± 16.8. Anemia was present in 23.2% (N = 55), and 36.7% (N = 87) experienced 2 or more exacerbations yearly. Impaired autonomy was seen in 49.4% (N = 117), and the updated Charlson Comorbidity Index (uCCI) averaged 2.2 ± 1.86. No significant difference was observed in SRI scores between age categories (P= 0.581), though uCCI varied significantly (P= 0.014). Regression analysis indicated that frequent exacerbations negatively affected SRI scores (Young group: -9.2; 95% CI = -14.8/ -3.55 vs Older group: -6.17; 95% CI = -11.91/ -0.43) and greater autonomy loss was linked to lower SRI scores (Level of Care 2 Young group: -13.91; 95% CI = -21.4/ -6.43 vs Older group: -14.94; 95% CI = -22.64/ -7.24). Anemia impacted SRI scores only in the younger category (Young group: -7.9; 95% CI = -14.0/ -1.75 vs older group: -1.78; 95% CI = -9.21/ 5.65).   

Investigators concluded that HRQL was similarly maintained across age groups, though it was more negatively impacted in younger individuals by anemia and in older adults by severe autonomy impairment. 

Source: bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-025-03737-3