Heparin-like sulfated or sulfonated mixes have been known for quite a long time for their capacity to forestall disease by heparan sulfate proteoglycan (HSPG)- dependent infections yet just in a reversible way. The gold nanoparticles and β-cyclodextrins covered with mercapto-undecane sulfonic corrosive (MUS) hinder HSPG-subordinate infections irreversibly while holding the low-poisonousness profile of most heparin-like mixes. For this study, main objective was to observe Sulfonated Nanomaterials with Broad-Spectrum Antiviral Activity Extending beyond Heparan Sulfate-Dependent Viruses. In this study it was shown that, in stark contrast to heparin, these compounds also inhibit different strains of influenza virus and vesicular stomatitis virus (VSV), which do not bind HSPG. As a conclusion we can say that the antiviral activity is virucidal and irreversible for influenza A virus (H1N1), while for VSV, there is a reversible restraint of viral connection to the cell. And also, these results will certainly further broaden the spectrum of various activity of MUS-coated gold nanoparticles and β-cyclodextrins.
Reference link- https://aac.asm.org/content/64/12/e02001-20
