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Hepatitis B and HTLV-1 co-infection in the Northern Territory, Australia.

Hepatitis B and HTLV-1 co-infection in the Northern Territory, Australia.
Author Information (click to view)

Marr I, Davies J, Baird RW,


Marr I, Davies J, Baird RW, (click to view)

Marr I, Davies J, Baird RW,

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International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2017 03 15() pii 10.1016/j.ijid.2017.03.010

Abstract
OBJECTIVE
To establish the relationship of Hepatitis B and HTLV-1 serological markers in the Northern Territory, Australia.

METHODS
A retrospective serological study of patients, presenting to public healthcare facilities, in the Northern Territory between 2008 and 2015, was performed to determine presence and relationships of serological markers of Hepatitis B virus (HBV), and Human T-cell Leukemic virus 1 (HTLV-1).

RESULTS
There were 740 individual cases of serological positive HTLV-1 identified over 8 years in the Northern Territory. In these patients, 521 had Hepatitis B results available. Hepatitis B surface antigen (HBVsAg) positivity was demonstrated in 83/521 (15.9%) of this cohort, which was significantly different to the HTLV-1 negative group, 125/3354 (3.7%), p <0.001. Excluding individuals with isolated surface antibody (sAb), those in the HTLV-1 positive group had a higher HBV exposure history, 352/521 (67.5%), when compared to HTLV-1 negative individuals, 1259/3354 (37.8%) (p <0.001). HTLV-1 positive individuals had lower prevalence of HBV combined HBVsAb and core antibody (HBVcAb) positive markers compared to those HTLV-1 negative, 198/352 (56.3%) versus 937/1269 (73.8%) p<0.001 respectively. CONCLUSIONS
Significantly higher prevalence rates of HBV are found in HTLV-1 positive individuals from the Northern Territory. When considering the higher exposure of HBV in HTLV-1 positive individual’s, clearance of HBV appears lower than those individuals testing HTLV-1 negative. Lower prevalence of clearance, as signified by formation of HBVcAb and HBVsAb in HTVL-1 positive individual’s may equate to higher prevalence of ongoing infection compared to those individuals HTLV-1 negative.

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