Advertisement

 

 

Hepatitis C viral load in HCV-monoinfected and HCV/HIV-1-, HCV/HTLV-1/-2-, and HCV/HIV/HTLV-1/-2-co-infected patients from São Paulo, Brazil.

Hepatitis C viral load in HCV-monoinfected and HCV/HIV-1-, HCV/HTLV-1/-2-, and HCV/HIV/HTLV-1/-2-co-infected patients from São Paulo, Brazil.
Author Information (click to view)

Alves FA, Campos KR, Lemos MF, Moreira RC, Caterino-de-Araujo A,


Alves FA, Campos KR, Lemos MF, Moreira RC, Caterino-de-Araujo A, (click to view)

Alves FA, Campos KR, Lemos MF, Moreira RC, Caterino-de-Araujo A,

Advertisement

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2018 04 03() pii 10.1016/j.bjid.2018.03.002

Abstract

Co-infections of hepatitis C virus (HCV) and either human immunodeficiency virus type 1 (HIV-1), human T-cell lymphotropic virus type 1 (HTLV-1) or type 2 (HTLV-2) have been described as having an impact on HCV viremia and subsequent disease progression. HCV load in serum samples from 622 patients (343 males, 279 females; median age 50.8 years) from São Paulo/southeast Brazil was analyzed using the Abbott Real Time HCV assay (Abbott Molecular Inc., IL, USA). Samples were obtained from HCV-monoinfected (n=548), HCV/HIV-1- (n=41), HCV/HTLV-1- (n=16), HCV/HTLV-2- (n=8), HCV/HIV/HTLV-1- (n=4), and HCV/HIV/HTLV-2-co-infected (n=5) patients, and results were compared among the groups and according to sex. The median HCV load in HCV-monoinfected patients was 5.23 logIU/mL and 0.31 loghigher in men than in women. Increases in viral load of 0.51 log, 0.54 log, and 1.43 logIU/mL were detected in HCV/HIV-1-, HCV/HTLV-1- and HCV/HIV/HTLV-1-co-infected individuals, respectively, compared with HCV-monoinfected counterparts. In contrast, compared to HCV/HIV co-infected patients, HCV/HTLV-2-co-infected patients had an HCV load of 5.0 logIU/mL, whereas HCV/HIV/HTLV-2-co-infected patients had a median load 0.37 logIU/mL lower. Significant differences in HCV loads were detected, with males and HCV/HIV-1- and HCV/HIV/HTLV-1-co-infected patients presenting the highest values. Conversely, females and HCV/HTLV-2-co-infected patients exhibited lower HCV loads. Overall, HCV viremia is increased in HIV and/or HTLV-1-co-infection and decreased in HTLV-2 co-infection.

Submit a Comment

Your email address will not be published. Required fields are marked *

9 − 8 =

[ HIDE/SHOW ]