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HHV8 and Kaposi’s sarcoma: should we really give up protease inhibitors in all HIV-infected patients?

HHV8 and Kaposi’s sarcoma: should we really give up protease inhibitors in all HIV-infected patients?
Author Information (click to view)

Philibert P, Chiche L, Caillères S, Allemand J, Rebaudet S, Delord M, Stavris C, Retornaz F, Khiri H, Halfon P,


Philibert P, Chiche L, Caillères S, Allemand J, Rebaudet S, Delord M, Stavris C, Retornaz F, Khiri H, Halfon P, (click to view)

Philibert P, Chiche L, Caillères S, Allemand J, Rebaudet S, Delord M, Stavris C, Retornaz F, Khiri H, Halfon P,

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AIDS (London, England) 31(15) 2167-2169 doi 10.1097/QAD.0000000000001588

Abstract

: We describe the first case of a patient presenting Kaposi’s sarcoma with human herpes virus 8 (HHV8) viremia after switching from a protease inhibitor to an integrase inhibitor-based combination antiretroviral therapy, followed by a rapid remission when resuming protease inhibitor. We suggest that the recent recommendations to switch all HIV patients to protease inhibitor-free regimens should be carefully re-evaluated especially in MSM HIV patients which are at higher risks of HHV8 infections and associated malignancies.

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