Advertisement

 

 

High HIV-1 RNA among Newly Diagnosed People in Botswana.

High HIV-1 RNA among Newly Diagnosed People in Botswana.
Author Information (click to view)

Novitsky V, Prague M, Moyo S, Gaolathe T, Mmalane M, Kadima Yankinda E, Chakalisa U, Lebelonyane R, Khan N, Powis KM, Widenfelt E, Gaseitsiwe S, Dryden-Peterson SL, Pretorius Holme M, De Gruttola V, Bachanas P, Makhema J, Lockman S, Essex M,


Novitsky V, Prague M, Moyo S, Gaolathe T, Mmalane M, Kadima Yankinda E, Chakalisa U, Lebelonyane R, Khan N, Powis KM, Widenfelt E, Gaseitsiwe S, Dryden-Peterson SL, Pretorius Holme M, De Gruttola V, Bachanas P, Makhema J, Lockman S, Essex M, (click to view)

Novitsky V, Prague M, Moyo S, Gaolathe T, Mmalane M, Kadima Yankinda E, Chakalisa U, Lebelonyane R, Khan N, Powis KM, Widenfelt E, Gaseitsiwe S, Dryden-Peterson SL, Pretorius Holme M, De Gruttola V, Bachanas P, Makhema J, Lockman S, Essex M,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

AIDS research and human retroviruses 2017 12 07() doi 10.1089/AID.2017.0214

Abstract
OBJECTIVE
HIV-1 RNA level is strongly associated with HIV transmission risk. We sought to determine whether HIV-1 RNA level was associated with prior knowledge of HIV status among treatment-naïve HIV-infected individuals in Botswana, a country with high rates of antiretroviral treatment (ART) coverage. This information may be helpful in targeting HIV diagnosis and treatment efforts in similar high-HIV-prevalence settings.

DESIGN
Population-based survey.

METHODS
HIV-infected individuals were identified during a household survey performed in 30 communities across Botswana. ART-naïve persons with detectable HIV-1 RNA (>400 copies/mL) were divided into two groups, newly diagnosed and individuals tested in the past who knew about their HIV infection at the time of household visit but had not taken ART. Levels of HIV-1 RNA were compared between groups, overall and by age and gender.

RESULTS
Among 815 HIV-infected ART-naïve persons with detectable virus, newly diagnosed individuals had higher levels of HIV-1 RNA (n=490, median HIV-1 RNA 4.35, IQR 3.79-4.91 log10 copies/mL) than those who knew about their HIV-positive status (n=325, median HIV-1 RNA 4.10, IQR 3.55-4.68 log10 copies/mL; p-values <0.001, but p-value =0.011 after adjusting for age and gender). A non-significant trend for higher HIV-1 RNA was found among newly diagnosed men aged 30 years or older (median HIV-1 RNA 4.58, IQR 4.07-5.02 log10 copies/mL vs. 4.17, 3.61-4.71 log10 copies/mL). CONCLUSIONS
Newly diagnosed individuals have elevated levels of HIV-1 RNA. This study highlights the need for early diagnosis and treatment of HIV infection for purposes of HIV epidemic control, even in a setting with high ART coverage.

Submit a Comment

Your email address will not be published. Required fields are marked *

ten − seven =

[ HIDE/SHOW ]