Advertisement

 

 

High prevalence of gastric intestinal metaplasia detected by confocal laser endomicroscopy in Zambian adults.

High prevalence of gastric intestinal metaplasia detected by confocal laser endomicroscopy in Zambian adults.
Author Information (click to view)

Kayamba V, Shibemba A, Zyambo K, Heimburger DC, Morgan DR, Kelly P,


Kayamba V, Shibemba A, Zyambo K, Heimburger DC, Morgan DR, Kelly P, (click to view)

Kayamba V, Shibemba A, Zyambo K, Heimburger DC, Morgan DR, Kelly P,

Advertisement

PloS one 2017 09 0812(9) e0184272 doi 10.1371/journal.pone.0184272
Abstract
BACKGROUND
Confocal laser endomicroscopy (CLE) may increase the detection of gastric premalignant lesions, and facilitate targeted biopsies for histology. The study aim was to analyse premalignant lesions in Zambian adults using CLE.

METHODS
Using CLE and histology we analysed the antral mucosa for gastric premalignant lesions in asymptomatic adults living with HIV and in HIV seronegative adults. Fasting gastric pH and the presence of Helicobacter pylori (H. pylori) were also evaluated.

RESULTS
We enrolled 84 HIV seropositive participants (median age 43 years; 55 (65%) female), of whom 32 (38%) were anti-retroviral therapy (ART)-naïve. Also enrolled were 22 HIV seronegative controls (median age 39 years, 12 (55%) females). Hypochlorhydria was found in 48 (57%) HIV positive and 8 (38%) HIV negative controls (P = 0.14). Detection of gastric intestinal metaplasia (GIM) was higher (P = 0.007) using CLE (49, 54%) than histology (9, 9%) and, using CLE, GIM was similar between HIV positive (41, 60%) and negative groups (8, 36%; P = 0.08). Gastric luminal fluorescein leakage was significantly associated with the presence of GIM [OR 8.2; 95% CI 2.5-31, P<0.001]. CONCLUSION
CLE is useful for the detection of GIM, and luminal fluorescein leakage may represent a novel CLE marker for GIM. GIM is common in Zambian adults, and is highly prevalent irrespective of HIV infection or use of ART.

Submit a Comment

Your email address will not be published. Required fields are marked *

three × four =

[ HIDE/SHOW ]