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High prevalence of HBV infection, detection of subgenotypes F1b, A2 and D4 and differential risk factors among Mexican risk populations with low socioeconomic status.

High prevalence of HBV infection, detection of subgenotypes F1b, A2 and D4 and differential risk factors among Mexican risk populations with low socioeconomic status.
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Jose-Abrego A, Panduro A, Fierro NA, Roman S,


Jose-Abrego A, Panduro A, Fierro NA, Roman S, (click to view)

Jose-Abrego A, Panduro A, Fierro NA, Roman S,

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Journal of medical virology 2017 08 09() doi 10.1002/jmv.24913

Abstract

Hepatitis B virus (HBV) infection may be underestimated among high-risk individuals in regions of low HBs antigenemia. This study aimed to assess HBV serological markers, genotypes and risk factors in Mexican patients with risk of HBV infection and low socioeconomic status. Demographics, clinical and risk factor data were collected in patients with HIV (n = 289), HCV (n = 243), deferred blood donors (D-BD) (n = 83), and two native populations, Mixtecos (n = 57) and Purepechas (n = 44). HBV infection was assessed by HBsAg, anti-HBc and HBV-DNA testing. Overall, patients had low education and very-low income. Totally, HBsAg prevalence was 16.5% (113/684) ranging from 0.7% (HCV) to 37.3% (D-BD), while anti-HBc was 30.2% (207/684). Among 52 sequences, genotypes H (n = 34, 65.4%), G (n = 4, 7.7%), subgenotypes F1b (n = 7,13.5%), A2 (n = 6,11.5%), and D4 (n = 1,1.9%) were detected. Surgeries, sexual promiscuity, and blood transfusions had a differential pattern of distribution. In HCV patients, single (OR = 5.84, 95%Cl 1.91-17.80, p = 0.002), MSM (OR = 4.80, 95%Cl 0.75-30.56, p = 0.097) and IDU (OR = 2.93, 95%CI 1.058-8.09, p = 0.039) were predictors for HBV infection. While IDU (OR = 2.68, 95%CI 1.08-6.61, p = 0.033) and MSM (OR = 2.64, 95%CI 1.39-5.04, p = 0.003) were predictors in HIV patients. In this group, MSM was associated with HBsAg positivity (OR= 3.45, 95% CI 1.48-8.07, p = 0.004) and IDU with anti-HBc positivity (OR = 5.12, 95%CI 2.05-12.77, p < 0.001). In conclusion, testing with a combined approach of three different HBV markers, a high prevalence of HBV infection, a differential distribution of HBV genotypes, including subgenotypes F1b, A2, and D4, as well as risk factors in low-income Mexican risk groups were detected. This article is protected by copyright. All rights reserved.

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