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High-speed, high-frequency ultrasound, in utero vector-flow imaging of mouse embryos.

High-speed, high-frequency ultrasound, in utero vector-flow imaging of mouse embryos.
Author Information (click to view)

Ketterling JA, Aristizábal O, Yiu BYS, Turnbull DH, Phoon CKL, Yu ACH, Silverman RH,


Ketterling JA, Aristizábal O, Yiu BYS, Turnbull DH, Phoon CKL, Yu ACH, Silverman RH, (click to view)

Ketterling JA, Aristizábal O, Yiu BYS, Turnbull DH, Phoon CKL, Yu ACH, Silverman RH,

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Scientific reports 2017 11 307(1) 16658 doi 10.1038/s41598-017-16933-x
Abstract

Real-time imaging of the embryonic murine cardiovascular system is challenging due to the small size of the mouse embryo and rapid heart rate. High-frequency, linear-array ultrasound systems designed for small-animal imaging provide high-frame-rate and Doppler modes but are limited in regards to the field of view that can be imaged at fine-temporal and -spatial resolution. Here, a plane-wave imaging method was used to obtain high-speed image data from in utero mouse embryos and multi-angle, vector-flow algorithms were applied to the data to provide information on blood flow patterns in major organs. An 18-MHz linear array was used to acquire plane-wave data at absolute frame rates ≥10 kHz using a set of fixed transmission angles. After beamforming, vector-flow processing and image compounding, effective frame rates were on the order of 2 kHz. Data were acquired from the embryonic liver, heart and umbilical cord. Vector-flow results clearly revealed the complex nature of blood-flow patterns in the embryo with fine-temporal and -spatial resolution.

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