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HIV-associatedblood stream infection is under-diagnosed by a single blood culture.

HIV-associatedblood stream infection is under-diagnosed by a single blood culture.
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Barr DA, Kerkhoff AD, Schutz C, Ward AM, Davies GR, Wilkinson RJ, Meintjes G,


Barr DA, Kerkhoff AD, Schutz C, Ward AM, Davies GR, Wilkinson RJ, Meintjes G, (click to view)

Barr DA, Kerkhoff AD, Schutz C, Ward AM, Davies GR, Wilkinson RJ, Meintjes G,

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Journal of clinical microbiology 2018 02 14() pii 10.1128/JCM.01914-17

Abstract

We assessed the additional diagnostic yield forblood stream infection (MTB BSI) from doing more than one TB blood culture in HIV-infected inpatients. In a retrospective analysis of two cohorts based in Cape Town, South Africa, 72/99 (73%) patients with MTB BSI were identified by the first of two blood cultures during the same admission, with 27/99 (27%, 95%CI 18 to 36%) negative on first culture but positive on second. In a prospective evaluation of up to 6 blood cultures over 24 hours, 9 out of 14 patients with MTB BSI (65%) grewon their first blood culture; 3 more patients (21%) were identified by a second independent blood culture at the same time point, and the remaining 2 diagnosed only on 4and 6blood cultures respectively. Additional blood cultures increase the yield for MTB BSI, similar to what is reported for non-mycobacterial BSI.

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