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HIV Infection Increases the Risk of Incident Psoriasis: A Nationwide Population-Based Cohort Study in Taiwan.

HIV Infection Increases the Risk of Incident Psoriasis: A Nationwide Population-Based Cohort Study in Taiwan.
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Yen YF, Jen IA, Chen M, Lan YC, Lee CY, Chuang PH, Lee Y, Arthur Chen YM,


Yen YF, Jen IA, Chen M, Lan YC, Lee CY, Chuang PH, Lee Y, Arthur Chen YM, (click to view)

Yen YF, Jen IA, Chen M, Lan YC, Lee CY, Chuang PH, Lee Y, Arthur Chen YM,

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Journal of acquired immune deficiency syndromes (1999) 75(5) 493-499 doi 10.1097/QAI.0000000000001431

Abstract
BACKGROUND
HIV can cause an imbalance of T lymphocytes, which may contribute to the onset of psoriasis. However, the association of HIV with incident psoriasis has not been extensively studied.

OBJECTIVES
The aim of this nationwide population-based cohort study was to determine the association of HIV with incident psoriasis.

METHODS
Since January 1, 2000, we identified adult people living with HIV/AIDS (PLWHA) from the Taiwan National Health Insurance Research Database. A control cohort without HIV infection, matched for age and sex, was selected for comparison. All patients were followed until December 31, 2012, and observed for the occurrence of psoriasis. The time-dependent Cox proportional hazards model was used to determine the association of HIV with incident psoriasis, while considering death as a competing risk event.

RESULTS
Of the 102,070 patients (20,294 PLWHA and 81,776 matched controls), 248 (0.24%) had incident psoriasis during a mean follow-up period of 5.53 years, including 81 (0.40%) PLWHA and 171 (0.21%) controls. After adjusting for age, sex, and comorbidities, HIV infection was found to be an independent risk factor for incident psoriasis (adjusted hazard ratio, 1.80; 95% confidence interval: 1.38 to 2.36).

CONCLUSIONS
The population of PLWHA is living longer; clinicians need to be aware of their higher risk of psoriasis.

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