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HIV prevalence and phylogenetic characteristics among entry travelers in Xishuangbanna prefecture, Yunnan Province, between 2003 and 2012.

HIV prevalence and phylogenetic characteristics among entry travelers in Xishuangbanna prefecture, Yunnan Province, between 2003 and 2012.
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Wang B, Liang Y, Wang Y, Feng Y, Li Y, Zhang L, Xuan Q, Miao J, Qin W, Xia X,


Wang B, Liang Y, Wang Y, Feng Y, Li Y, Zhang L, Xuan Q, Miao J, Qin W, Xia X, (click to view)

Wang B, Liang Y, Wang Y, Feng Y, Li Y, Zhang L, Xuan Q, Miao J, Qin W, Xia X,

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Journal of medical virology 2016 12 06() doi 10.1002/jmv.24740

Abstract

Xishuangbanna is a popular tourist destination in southern Yunnan Province, bordering with Vietnam and Laos and Myanmar. There are more than 2 million cross-border travelers annually entering China at two land ports, Daluo and Mohan. To clarify the characteristics of HIV-1 prevalence among entry travelers, a retrospective epidemic investigation was conducted. Between 2003 and 2012, 196 among 91,432 entry travelers were detected to be HIV-1-positive, accounting for infection rate of 0.21%. Eighty-one gag-pol gene sequences were obtained for phylogenetic analyses and subsequent recombination analysis. It was shown that the most prevalent HIV-1 subtype in this population was circulating recombinant form (CRF) 01_AE (42, 51.86%), followed by CRF08_BC (17, 20.99%), CRF07_BC (4, 4.94%), B’ (2, 2.47%), C (2, 2.47%), other recombinants (9, 11.11%), and undefined subtype (5, 6.17%). HIV-1 genotype distribution among travelers entering at two land ports is different, CRF01_AE and CRF08_BC accounted for a larger percentage among individuals from Daluo, whereas the proportions of subtype C and undefined URFs were larger among individuals from Mohan. The undefined subtype indicates the occurrence of novel HIV-1 subtype or CRF. This finding is useful for developing of AIDS prevention strategies. This article is protected by copyright. All rights reserved.

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