Clinical practice guidelines (CPGs) are systematically developed statements to assist practitioners in patient decisions about appropriate health care. Appropriate methodologies and rigorous strategies are required to achieve high-quality CPGs. However, several challenges may occur during the development of guidelines. This article highlights current hot topics related to the development of guidelines for the management of non-neurogenic male lower urinary tract symptoms (LUTS) including benign prostatic obstruction (BPO). Challenges include: (1) periodic updating of guidelines because of the rapid and continuous accumulation of new evidence and a range of emerging treatment options; (2) the requirements for inclusion of new interventions in guidelines; (3) inclusion of the values and preferences of patients with LUTS who have different needs and characteristics; and (4) a need to improve guideline implementation and adherence. Actions to overcome these challenges are also discussed. PATIENT SUMMARY: Guidelines are considered to improve the quality of clinical decisions by helping doctors and contributing to the consistency of care. The development and successful translation into clinical practice of guidelines on male lower urinary tract symptoms require management of several issues, including the identification and incorporation of patients’ values and preferences.
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