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How entry inhibitors synergize to fight HIV.

How entry inhibitors synergize to fight HIV.
Author Information (click to view)

Melikyan GB,


Melikyan GB, (click to view)

Melikyan GB,

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The Journal of biological chemistry 292(40) 16511-16512 doi 10.1074/jbc.H117.791731

Abstract

HIV fusion with the cell membrane can be inhibited by blocking coreceptor binding or by preventing fusion-inducing conformational changes in the Env protein. Logically, inhibitors that act by these two mechanisms should act synergistically, but previous studies have reported conflicting results. A new study by Ahn and Root reconciles these discordant reports by demonstrating that synergy emerges when Env engages multiple coreceptors prior to inducing fusion and when high-affinity inhibitory peptides are used, a condition that may not be satisfied in vivo.

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