Advertisement

 

 

Human Immunodeficiency Virus Infection Increases the Risk of Incident Autoimmune Hemolytic Anemia: A Population-Based Cohort Study in Taiwan.

Human Immunodeficiency Virus Infection Increases the Risk of Incident Autoimmune Hemolytic Anemia: A Population-Based Cohort Study in Taiwan.
Author Information (click to view)

Yen YF, Lan YC, Huang CT, Jen IA, Chen M, Lee CY, Chuang PH, Lee Y, Morisky DE, Chen YA,


Yen YF, Lan YC, Huang CT, Jen IA, Chen M, Lee CY, Chuang PH, Lee Y, Morisky DE, Chen YA, (click to view)

Yen YF, Lan YC, Huang CT, Jen IA, Chen M, Lee CY, Chuang PH, Lee Y, Morisky DE, Chen YA,

Advertisement

The Journal of infectious diseases 216(8) 1000-1007 doi 10.1093/infdis/jix384

Abstract
Background
Currently, the association between human immunodeficiency virus (HIV) infection and subsequent development of autoimmune hemolytic anemia (AIHA) remains unclear. This nationwide population-based cohort study aimed to determine the association between incident AIHA and HIV infection in Taiwan.

Methods
During 2000-2012, we identified people aged ≧15 years living with HIV (PLWH) from the Taiwan Centers for Disease Control HIV Surveillance System. Individuals were considered to be infected with HIV on the basis of positive results of an HIV type 1 Western blot. Age- and sex-matched controls without HIV infection were selected from the Taiwan National Health Insurance Research Database for comparison. All patients were followed until 31 December 2012 and observed for occurrence of AIHA.

Results
Of 171468 subjects (19052 PLWH and 152416 controls), 30 (0.02%) had incident AIHA during a mean follow-up of 5.45 years, including 23 PLWH (0.12%) and 7 controls (0.01%). After adjustment for age, sex, and comorbidities, HIV infection was found to be an independent risk factor of incident AIHA (adjusted hazard ratio, 20.9; 95% confidence interval, 8.34-52.3). Moreover, PLWH who were receiving highly active antiretroviral therapy were more likely to develop AIHA than those who were not receiving these drugs (adjusted hazard ratio, 16.2; 95% confidence interval, 3.52-74.2).

Conclusions
Our study suggests that HIV infection is an independent risk factor for incident AIHA.

Submit a Comment

Your email address will not be published. Required fields are marked *

nineteen − 10 =

[ HIDE/SHOW ]