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Human T-lymphotropic virus 1aA circulation and risk factors for sexually transmitted infections in an Amazon geographic area with lowest human development index (Marajó Island, Northern Brazil).

Human T-lymphotropic virus 1aA circulation and risk factors for sexually transmitted infections in an Amazon geographic area with lowest human development index (Marajó Island, Northern Brazil).
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de Aguiar SA, de Souza França SA, Santana BB, Santos MB, Freitas FB, Ferreira G, Cayres-Vallinoto I, Ishak MOG, Ishak R, Vallinoto ACR,


de Aguiar SA, de Souza França SA, Santana BB, Santos MB, Freitas FB, Ferreira G, Cayres-Vallinoto I, Ishak MOG, Ishak R, Vallinoto ACR, (click to view)

de Aguiar SA, de Souza França SA, Santana BB, Santos MB, Freitas FB, Ferreira G, Cayres-Vallinoto I, Ishak MOG, Ishak R, Vallinoto ACR,

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BMC infectious diseases 2017 12 0817(1) 758 doi 10.1186/s12879-017-2859-x

Abstract
BACKGROUND
This cross-sectional study evaluated the prevalence of infection with human T-lymphotropic virus 1 and 2 (HTLV-1 and HTLV-2) in a population from the municipalities of Anajás, Chaves, São Sebastião da Boa Vista (SSBV) and Portel in the Marajó Archipelago and correlated these data with the epidemiological characteristics of the study population.

METHODS
A total of 1899 biological samples were evaluated. The samples were screened for the presence of anti-HTLV antibodies using an enzyme-linked immunosorbent assay (ELISA), and infection was confirmed using conventional polymerase chain reaction (PCR), real-time PCR and nucleotide sequencing.

RESULTS
Eleven samples (0.58%) were seropositive for HTLV, but molecular analysis confirmed positivity in only two samples (0.11%). Nucleotide sequencing and phylogenetic analysis indicated that the two samples positive for HTLV-1 that were isolated in Chaves belonged to the Cosmopolitan subtype 1 (HTLV-1a) and Transcontinental subgroup (A).

CONCLUSION
Our results confirmed the presence of Cosmopolitan Transcontinental HTLV-1 in the Marajó Archipelago, Amazon region, and the majority of the population revealed a lack of knowledge about sexually transmitted infections, which increases the risk of dissemination of HTLV and other agents.

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