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Humoral Response of Buffaloes to a Recombinant Vaccine against Botulism Serotypes C and D.

Humoral Response of Buffaloes to a Recombinant Vaccine against Botulism Serotypes C and D.
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Otaka DY, Barbosa JD, Moreira C, Ferreira MRA, Cunha CEP, Brito ARS, Donassolo RA, Moreira ÂN, Conceição FR, Salvarani FM,


Otaka DY, Barbosa JD, Moreira C, Ferreira MRA, Cunha CEP, Brito ARS, Donassolo RA, Moreira ÂN, Conceição FR, Salvarani FM, (click to view)

Otaka DY, Barbosa JD, Moreira C, Ferreira MRA, Cunha CEP, Brito ARS, Donassolo RA, Moreira ÂN, Conceição FR, Salvarani FM,

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Toxins 2017 09 229(10) pii E297
Abstract

Botulism is a fatal intoxication caused by botulinum neurotoxins (BoNTs), which are mainly produced by Clostridium botulinum and characterized by flaccid paralysis. The BoNTs C and D are the main serotypes responsible for botulism in animals, including buffaloes. Botulism is one of the leading causes of death in adult ruminants in Brazil due to the high mortality rates, even though botulism in buffaloes is poorly reported and does not reflect the real economic impact of this disease in Brazilian herds. Vaccination is reported as the most important prophylactic measure for botulism control, although there are no specific vaccines commercially available for buffaloes in Brazil. This study aimed to evaluate the humoral immune response of buffalo groups vaccinated with three different concentrations of recombinant proteins (100, 200, and 400 µg) against BoNTs serotypes C and D as well as to compare the groups to each other and with a group vaccinated with a bivalent commercial toxoid. The recombinant vaccine with a concentration of 400 μg of proteins induced the highest titers among the tested vaccines and was proven to be the best choice among the formulations evaluated and should be considered as a potential vaccine against botulism in buffalo.

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