IUBMB life 2018 03 30() doi 10.1002/iub.1740
An increasing number of studies have established hydrogen sulfide (HS) gas as a major cytoprotectant and redox modulator. Following its discovery, HS has been found to have pleiotropic effects on physiology and human health. HS acts as a gasotransmitter and exerts its influence on gastrointestinal, neuronal, cardiovascular, respiratory, renal, and hepatic systems. Recent discoveries have clearly indicated the importance of HS in regulating vasorelaxation, angiogenesis, apoptosis, ageing, and metabolism. Contrary to studies in higher organisms, the role of HS in the pathophysiology of infectious agents such as bacteria and viruses has been less studied. Bacterial and viral infections are often accompanied by changes in the redox physiology of both the host and the pathogen. Emerging studies indicate that bacterial-derived HS constitutes a defense system against antibiotics and oxidative stress. The HS signaling pathway also seems to interfere with redox-based events affected on infection with viruses. This review aims to summarize recent advances on the emerging role of HS gas in the bacterial physiology and viral infections. Such studies have opened up new research avenues exploiting HS as a potential therapeutic intervention. © 2018 The Authors IUBMB Life published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology, 2018.