Hypersensitivity to PPD and related compounds induced by temporary black henna tattoos has become a serious health problem worldwide. Various patterns of sensitization with various clinical aspects are described in literature due to PPD associated with henna tattoo. These manifestations are likely correlated with the immunological and dermatological mechanisms involved.

Henna is a plant Lawsonia inermis, Fam. Lythraceae. It is a woody shrub that mainly grows in regions of North Africa, South Asia, India, and Sri Lanka. It is frequent to see temporary “tattoos” performed with henna. To make tattoos darker and long-lasting PPD has been associated with it, so obtaining “black henna”. In these years there has been a rise of contact sensitization to PPD and in the medical literature. This abruptly increased number of cases have been reported on a temporary henna tattoo application.

Basically, the main focus of the review was the various clinical patterns related to PPD and henna tattoo. The purpose was to investigate the possible link between clinic-morphological pictures and the immunological response to PPD and henna. Different clinical manifestations are related to black henna containing PPD.

Reference: https://clinicalmolecularallergy.biomedcentral.com/articles/10.1186/s12948-017-0063-6