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The following is a summary of “Renal Denervation for Hypertension: From Innovation to Indication,” published in the April 2025 issue of American Journal of Cardiology by Townsend et al.

Hypertension remains a major public health concern and is universally recognized as the most important modifiable risk factor for mortality and organ damage involving the heart, brain, and kidneys. Although clinical guidelines differ slightly in defining the threshold for intervention, there is broad consensus regarding the critical impact of elevated blood pressure on health outcomes.

In the United States, hypertension affects more than two out of every five adults, with prevalence increasing steadily with age. It is estimated that over 100 million individuals in the U.S. are currently diagnosed with hypertension. This condition is directly linked to approximately 670,000 deaths annually, highlighting its significant contribution to the nation’s overall mortality burden. Moreover, the prevalence and impact of hypertension extend beyond national borders; globally, it remains the leading cause of disease burden, regardless of a country’s economic status.

Despite the availability of effective antihypertensive medications and recommended lifestyle modifications, blood pressure control remains inadequate for many patients. Persistent uncontrolled hypertension places individuals at substantial risk for severe vascular complications, including myocardial infarction, heart failure, chronic kidney disease, and stroke. These complications not only increase mortality but also contribute heavily to healthcare costs and diminished quality of life.

Addressing this ongoing challenge requires a multifaceted approach. Enhancing early diagnosis, promoting adherence to both pharmacologic treatments and lifestyle interventions, and implementing public health strategies focused on hypertension awareness and management are crucial steps. Without significant improvements in blood pressure control rates, the global burden of hypertension-related morbidity and mortality is likely to escalate further.

In summary, hypertension continues to represent a critical and preventable threat to global health. Efforts to standardize care, expand access to treatment, and prioritize preventive strategies are essential to reduce its widespread impact.

Source: ajconline.org/article/S0002-9149(25)00255-3/abstract