Kardiologia polska 2017 07 17() doi 10.5603/KP.a2017.0148
Prevalence of cardiovascular diseases (CVD) in HIV infected patients increases with aging and duration of the disease. Hypertension (HA), high cholesterol level obesity, diabetes, tobacco exposure and use of alcohol are among the traditional risk factors that contribute to CVD.
was to determinate the incidence of HA, lipid disturbances and CVD risk in dependence on clinical, viral and biochemical factors.
Four hundred and seventeen HIV infected Caucasian adult patients from the four clinical centers in Poland were enrolled and analyzed on the basis of available medical data from the years 2013-2015.
HA was diagnosed in 28% of all patients and in age ranges: < 40, between 41-60 and > 60 in 18%, 43% and 53% respectively. Percentage of optimal, normal and high normal blood pressure was: 28%, 14% and 30% respectively. Hypertension grade I, II and III was observed in 58%, 35% and 7% of patients, respectively. Factors associated with HA were: increasing age, male sex, increased BMI, hypercholesterolemia, hypo-HDL, hypertriglyceridemia and duration of HIV infection more than 10 years. Hypercholesterolemia, suboptimal level of HDL, elevated LDL and hypertriglyceridemia were observed in 37%, 20.5%, 31% and 52% respectively. Hypertriglyceridemia was associated with protease inhibitors based highly active antiretroviral therapy. HCV infection was negatively associated with hypercholesterolemia. Cigarette smoking was reported in 55% of cases.
Incidence of HA in particular age groups of HIV infected people is higher than in general Polish population. Hypertension is influenced by traditional risk factors and duration of HIV infection but not antiretroviral treatment. HIV/HCV coinfection appears to be protective against hypercholesterolemia.