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Hypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study.

Hypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study.
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Ren Y, Liu Y, Sun X, Deng K, Wang C, Li L, Zhang L, Wang B, Zhao Y, Zhou J, Han C, Zhang H, Yang X, Luo X, Pang C, Yin L, Feng T, Zhao J, Zhang M, Hu D,


Ren Y, Liu Y, Sun X, Deng K, Wang C, Li L, Zhang L, Wang B, Zhao Y, Zhou J, Han C, Zhang H, Yang X, Luo X, Pang C, Yin L, Feng T, Zhao J, Zhang M, Hu D, (click to view)

Ren Y, Liu Y, Sun X, Deng K, Wang C, Li L, Zhang L, Wang B, Zhao Y, Zhou J, Han C, Zhang H, Yang X, Luo X, Pang C, Yin L, Feng T, Zhao J, Zhang M, Hu D,

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Scientific reports 2017 08 227(1) 9072 doi 10.1038/s41598-017-09136-x
Abstract

Limited information is available on the effect of hypertriglyceridemia-waist (HTGW) combination and its dynamic status on the risk of type 2 diabetes mellitus (T2DM) in rural China. A cohort of 12,086 participants 18 to 92 years old was retained in this study. Kaplan-Meier analysis yielded the cumulative incidence of T2DM for each phenotype group (based on TG level and waist circumference [WC] at baseline). Cox regression yielded hazard ratios relating HTGW (based on TG level and WC at baseline and follow-up) to risk of developing T2DM. After a median follow-up of 6.0 years (71,432 person-years of follow-up), T2DM developed in 621 participants. For HTGW participants, the incidence of T2DM was 26.4/1000, 20.6/1000, and 21.9/1000 person-years for males, females, and overall, respectively. The adjusted HR for HTGW associated with T2DM was 7.63 (95% CI 4.32-13.49) for males and 7.75 (4.71-12.78) for females. Compared with consistent HTGW, with transformation from baseline HTGW to normal WC and normal triglycerides level at follow-up, the risk of developing T2DM was reduced by 75% and 78% for males and females. HTGW is a major risk factor for T2DM, but the risk could be reduced by improved triglycerides level and WC.

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