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Hypoxia Increases Thyroid Cancer Stem Cell-Enriched Side Population.

Hypoxia Increases Thyroid Cancer Stem Cell-Enriched Side Population.
Author Information (click to view)

Mahkamova K, Latar N, Aspinall S, Meeson A,


Mahkamova K, Latar N, Aspinall S, Meeson A, (click to view)

Mahkamova K, Latar N, Aspinall S, Meeson A,

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World journal of surgery 42(2) 350-357 doi 10.1007/s00268-017-4331-x

Abstract
INTRODUCTION
Hypoxic stress is a feature of rapidly growing thyroid tumours. Cancer progression is thought to be driven by a small population of tumour cells possessing stem cell properties. Hypoxia-inducible factors (HIFs) are important mediators of hypoxia. Both HIF-1alpha and HIF-2alpha have been reported to be expressed in thyroid cancers. There is growing evidence that the HIF pathway plays a significant role in the maintenance of thyroid cancer stem cells (CSC).

METHODOLOGY
We have isolated thyroid CSC from a papillary thyroid cancer-derived cell line (BCPAP) and an anaplastic thyroid cancer-derived cell line (SW1736) as side population (SP) cells (a putative stem cell population) and treated them with cobalt chloride (II) to induce hypoxia. RESULTS AND DISCUSSION: We observed an increase in the SP of cells within the thyroid cancer cell lines following induction of hypoxia.

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