The Particulars: Data are lacking on the burden of Clostridium difficile infection (CDI) recurrence.

Data Breakdown: For a study, investigators used a long-term, large sample database and a matching algorithm to adjust for the confounding effect of patient baseline characteristics and comorbidities. The clinical outcomes and healthcare resource use of patients with a single CDI episode were compared with those of patients with recurrent infection from 2001 to 2010. The study team observed the following:

  Patients with recurrent CDI Patients with non-recurrent CDI
Mortality rate 20.2% 15.3%
ED visits per year 1.7 visits 1.3 visits
Days of overnight hospitalization 9.7 days 5.7 days
ICU days 1.1 days 0.6 days

Take Home Pearls:
Recurrent CDI appears to be associated with worse patient outcomes and a greater burden of resource use when compared with non-recurrent CDI. Identifying patients at increased risk for recurrence and preventing such recurrences is crucial to averting serious CDI-related complications.