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The following is a summary of “Detection, mechanisms, and therapeutic implications of oncometabolites,” published in the December 2023 issue of Endocrinology by Cai, et al.
Metabolic anomalies in cancer cells help tumors grow. These aberrations are essential for cancer development and define malignant cells. Understanding and addressing metabolic alterations is crucial to creating successful cancer therapy and care techniques. By studying cancer cells’ metabolism, researchers hoped to find novel treatments that may stop tumor development and improve patient outcomes. In cancer biology, oncometabolites affect oncogenesis, metabolism, and treatment resistance.
These pleiotropic chemicals affect various cancer growth and progression factors. By modifying biological pathways, oncometabolites shape cancer cell behavior and features. They are vital to cancer research because their effect spans several aspects of cancer biology. By targeting oncometabolites, tumor growth may be slowed, and treatment results may improve. Identifying and targeting these metabolites may help overcome therapy resistance. This cancer treatment method has enormous potential for improving patient outcomes and advancing oncology.
Scientists have better-understood cancer cell metabolic patterns. These discoveries have illuminated cancer’s complex processes and metabolic networks. They were learning more about tumor development and survival by studying cancer cell metabolism. Cancer treatment needs this information to produce tailored medicines and improve patient outcomes. They examined oncometabolite detection, molecular processes, and therapeutic targets in the study. Exploring these elements helps them understand how cometabolism may be addressed for cancer treatment. Researchers and doctors may use this review to get a complete picture of the field.
Source: sciencedirect.com/science/article/abs/pii/S1043276023001856
